Potential for automatic detection of calving in beef cows grazing on rangelands from Global Navigate Satellite System collar data.

Dystocia is one of the main causes of calf death around calving. In addition, peripartum deaths may occur due to other factors, such as weather or predators, especially in the case of grazing animals. Precision Livestock Farming (PLF) tools aimed at the automatic detection of calving may be useful for farmers, allowing cow assistance in case of dystocia or checking the condition of the cow-calf pair after calving. Such PLF systems are commercially available for dairy cows, but these tools are not suitable for rangelands, mainly due to power and connectivity constraints. Thus, since most commercial PLF tools for rangelands are based on Global Navigate Satellite System (GNSS) technology, the objective of this study was to design and evaluate several indicators built from data gathered with GNSS collars to characterise their potential for the detection of calving on rangelands. Location data from 57 cows, 42 of which calved during the study, were curated and analysed following a standardised procedure. Several indicators were calculated using two different strategies. The first approach consisted of having indicators that could be computed using the data of a single GNSS collar (cow indicators). The second strategy involved the use of data from several animals (herd indicators), which requires more animals to be monitored, but may allow the characterisation of social behaviour. Several indicators, such as the length of the daily trajectory or the sinuosity of cow path, showed significant differences between the pre- and postpartum periods, but no clear differences between calving day and previous days. Herd indicators, such as the distance to herd centroid or to the nearest peer were superior in terms of the detection of calving day, as cows showed isolation behaviour from 24 hours before calving. Relative indicators, i.e., the value of cow or herd indicators for the calving cow in relation to the average value of the same indicators for its herdmates, provided additional information on cow behaviour. For instance, according to the relative indicator for the change in daily trajectory, pregnant cows had a differential exploratory behaviour up to 14 days before calving. In conclusion, data from commercial GNSS collars proved to be useful for the computation of several indicators related to the occurrence of calving on rangelands. Some of those indicators showed changes from baseline values on the day before calving, which could serve to predict the onset of parturition.

Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aß prions.

The amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of Guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein Lewy bodies, and sparse ß-amyloid (Aß) plaques distributed in the central nervous system. Extensive studies of genetic or environmental factors have failed to identify a cause of ALS-PDC. Building on prior work describing the detection of tau and Aß prions in Alzheimer's disease (AD) and Down syndrome brains, we investigated ALS-PDC brain samples for the presence of prions. We obtained postmortem frozen brain tissue from 26 donors from Guam with ALS-PDC or no neurological impairment and 71 non-Guamanian donors with AD or no neurological impairment. We employed cellular bioassays to detect the prion conformers of tau, α-synuclein, and Aß proteins in brain extracts. In ALS-PDC brain samples, we detected high titers of tau and Aß prions, but we did not detect α-synuclein prions in either cohort. The specific activity of tau and Aß prions was increased in Guam ALS-PDC compared with sporadic AD. Applying partial least squares regression to all biochemical and prion infectivity measurements, we demonstrated that the ALS-PDC cohort has a unique molecular signature distinguishable from AD. Our findings argue that Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aß prions.

Patient-centered outcomes after surgical treatment of peri-implantitis: a prospective clinical study.

BACKGROUND: Peri-implantitis is an inflammatory process affecting soft and hard tissues surrounding dental implants, causing progressive marginal bone loss. Peri-implant surgery is the treatment of choice. However, evidence about its impact on patients' quality of life (QoL) is limited. This study aimed to assess pain and QoL in the first seven post-operative days and measure patient satisfaction at the end of this period. MATERIAL AND METHODS: A prospective cohort study was conducted in patients with peri-implantitis. Patients reported pain on a visual analogue scale (VAS) ranging from 0 to 100mm every day during the first week after surgery. They then completed the OHIP-14sp questionnaire. A descriptive and inferential data analysis was used to assess the effect of surgical approach (resective, regenerative or combined), gender and working status on pain, satisfaction and QoL. RESULTS: Forty-one patients (93,2%) completed the daily pain VAS; scores ranged from 0 to 95 mm. Gender, occupation, or type of surgery had no significant effect upon its evolution. The mean total OHIP-14sp score was 16.7 (range = 5 to 33), indicating low to moderate deterioration in perceived oral health. Postoperative OHRQoL was significantly higher in working patients (mean difference (MD): 3.94; P = 0.042), and with the regenerative (MD: 6.34; P = 0.044) or the combined approach (MD: 5.41; P = 0.027). CONCLUSIONS: Considering the limitations of this study, postoperative pain was mild to moderate and decreased after the third day. Surgical treatment of peri-implantitis has an impact on QoL, especially when augmentation procedures are involved. This impact is higher in working patients.

Assessment of the patient safety culture in the ICU of a second level hospital at the end of the third COVID-19 wave.

INTRODUCTION: Current healthcare settings and ICUs especially are complex, highly technical, and multidisciplinary, with interactions between healthcare professionals and users, in which there may be errors at different levels. Our objective was to assess the perception of patient safety in our unit at the end of the third wave of the COVID pandemic, with the intention of conducting subsequent improvement actions. METHODS: Observational, cross-sectional, and descriptive study. The perception of Safety Culture was estimated using the HSOPS questionnaire translated into Spanish. Some questions were posed in a positive sense, and others in a negative sense. The response was also rated as positive, negative, or neutral. Our findings were compared visually, not mathematically, with those found in the previous national study «Analysis of the culture on patient safety in the hospital setting of the Spanish National Health System¼ published in 2009. A subgroup analysis was performed according to professional group and seniority as a health worker. The Student's t, χ2 and ANOVA tests were used. RESULTS: Sixty-two professionals responded to the questionnaire, 73.90% of the total. The median time working in ICU 2 years (interquartile range 2-4.5 years). The rating for the degree of safety was 8.06 (SD 1.16). The majority (91.20%) had not reported any adverse event in the last year. A total of 30.90% had recently received patient safety training. The dimensions considered as weaknesses were 9 ("Staffing", with 27.57% of positive responses) and 10 ("Support of the hospital management in safety", with 17.64% of positive responses). The dimensions considered as strengths were 3 ("Expectation of actions by management/supervision of the service") with 85.29% of positive responses, and 5 ("Teamwork") with 95.58% of positive responses. The Cronbach's alpha index values suggest that the questionnaire has adequate internal consistency. In general, our data are more positive than those collected in the 2011 national survey, although the 2 dimensions considered weaknesses were already considered such in the previous work. CONCLUSIONS: The perception of patient safety in the ICU of our hospital after the end of the third wave of the COVID pandemic is adequate, with a more positive rating than that of the national study on safety culture at the hospital level carried out in 2009. The constant quest for patient safety should prioritize activity in the 2 dimensions considered weaknesses: staffing, and support from hospital management in everything related to patient safety.

Valoración de la cultura de seguridad del paciente en la UCI de un hospital de segundo nivel al finalizar la tercera oleada de COVID-19 / Assessment of the patient safety culture in the ICU of a second level hospital at the end of the third COVID-19 wave

Introducción: El ambiente sanitario actual y, especialmente, las UCI, sen un medio complejo, altamente tecnificado y multidisciplinar, con interacciones entre los profesionales sanitarios y los usuarios, en los que puede haber errores a distinto nivel. Nuestro objetivo fue valorar la percepción de seguridad del paciente en nuestra unidad al terminar la tercera ola de la pandemia de COVID-19, con la intención de llevar a cabo acciones de mejora posteriores. Métodos: Estudio observacional, transversal y descriptivo. La percepción sobre la cultura de seguridad se estimó mediante el cuestionario HSOPS traducido al castellano. Algunas preguntas se plantearon en sentido positivo y otras en sentido negativo. También se calificó la respuesta como positiva, negativa o neutra. Se compararon visualmente, no de forma matemática, nuestros hallazgos con los encontrados en el estudio nacional previo «Análisis de la cultura sobre seguridad del paciente en el ámbito hospitalario del Sistema Nacional de Salud español» publicado en 2009. Se realizó un análisis de subgrupos en función del grupo profesional y de la antigüedad como sanitario. Se emplearon las pruebas t de Student, χ? y ANOVA. Resultados: Respondieron al cuestionario 62 profesionales, el 73,90% del total. La mediana del tiempo de trabajo en UCI fue 2 años (rango intercuartil 2-4,5 años). La calificación del grado de seguridad fue 8,06 (DE 1,16). La mayoría (91,20%) no había notificado ningún evento adverso en el último año. Un 30,90% había recibido formación en seguridad de paciente recientemente. Las dimensiones consideradas como debilidad fueron la 9 («Dotación del personal», con 27,57% de respuestas positivas) y la 10 («Apoyo de la gerencia del hospital en la seguridad», con 17,64% de respuestas positivas).(AU)

Introduction: Current healthcare settings and ICUs especially are complex, highly technical, and multidisciplinary, with interactions between healthcare professionals and users, in which there may be errors at different levels. Our objective was to assess the perception of patient safety in our unit at the end of the third wave of the COVID pandemic, with the intention of conducting subsequent improvement actions. Methods: Observational, cross-sectional, and descriptive study. The perception of Safety Culture was estimated using the HSOPS questionnaire translated into Spanish. Some questions were posed in a positive sense, and others in a negative sense. The response was also rated as positive, negative, or neutral. Our findings were compared visually, not mathematically, with those found in the previous national study «Analysis of the culture on patient safety in the hospital setting of the Spanish National Health System» published in 2009. A subgroup analysis was performed according to professional group and seniority as a health worker. The Student's t, χ? and ANOVA tests were used. Results: Sixty-two professionals responded to the questionnaire, 73.90% of the total. The median time working in ICU 2 years (interquartile range 2-4.5 years). The rating for the degree of safety was 8.06 (SD 1.16). The majority (91.20%) had not reported any adverse event in the last year. A total of 30.90% had recently received patient safety training. The dimensions considered as weaknesses were 9 («Staffing», with 27.57% of positive responses) and 10 (“Support of the hospital management in safety”, with 17.64% of positive responses). The dimensions considered as strengths were 3 («Expectation of actions by management / supervision of the service») with 85.29% of positive responses, and 5 («Teamwork») with 95.58% of positive responses.(AU)

Proposing a sustainable urban 3D model to minimize the potential risk associated with green infrastructure by applying engineering tools.

The goal of this study is to estimate the potential risk of exposure to urban green infrastructure by calculating and improving of AIROT index, adding meteorological factors as wind direction and updating the index to be more accurate for smaller urban green areas. To achieve this objective, BIM methodology has been applied by creating a 3D BIM model from the reality capture of a street with LiDAR. The BIM model contains the parametric data needed to apply AIROT index and it allows to map results in a graphic environmental sustainability study. The importance of location of green infrastructure is one of main conclusions obtained in order to minimize aerobiological risks in future new buildings or even in maintenance tasks of urban green infrastructure. A valuable result obtained from the developed methodology are walk simulations in the 3D model with the aim to identify high risk of potential exposure of urban green infrastructure with allergenic interest for allergic patients in order to supply health itineraries of pedestrians in a proposal of Smart City.

[Assessment of the patient safety culture in the ICU of a second level hospital at the end of the third COVID-19 wave]. / Valoración de la cultura de seguridad del paciente en la UCI de un hospital de segundo nivel al finalizar la tercera oleada de COVID-19.

Introduction: Current healthcare settings and ICUs especially are complex, highly technical, and multidisciplinary, with interactions between healthcare professionals and users, in which there may be errors at different levels. Our objective was to assess the perception of patient safety in our unit at the end of the third wave of the COVID pandemic, with the intention of conducting subsequent improvement actions. Methods: Observational, cross-sectional, and descriptive study. The perception of Safety Culture was estimated using the HSOPS questionnaire translated into Spanish. Some questions were posed in a positive sense, and others in a negative sense. The response was also rated as positive, negative, or neutral. Our findings were compared visually, not mathematically, with those found in the previous national study «Analysis of the culture on patient safety in the hospital setting of the Spanish National Health System¼ published in 2009. A subgroup analysis was performed according to professional group and seniority as a health worker. The Student's t, χ? and ANOVA tests were used. Results: Sixty-two professionals responded to the questionnaire, 73.90% of the total. The median time working in ICU 2 years (interquartile range 2-4.5 years). The rating for the degree of safety was 8.06 (SD 1.16). The majority (91.20%) had not reported any adverse event in the last year. A total of 30.90% had recently received patient safety training. The dimensions considered as weaknesses were 9 («Staffing¼, with 27.57% of positive responses) and 10 ("Support of the hospital management in safety", with 17.64% of positive responses). The dimensions considered as strengths were 3 («Expectation of actions by management / supervision of the service¼) with 85.29% of positive responses, and 5 («Teamwork¼) with 95.58% of positive responses. The Cronbach's alpha index values suggest that the questionnaire has adequate internal consistency. In general, our data are more positive than those collected in the 2011 national survey, although the 2 dimensions considered weaknesses were already considered such in the previous work. Conclusions: The perception of patient safety in the ICU of our hospital after the end of the third wave of the COVID pandemic is adequate, with a more positive rating than that of the national study on safety culture at the hospital level carried out in 2009. The constant quest for patient safety should prioritize activity in the 2 dimensions considered weaknesses: staffing, and support from hospital management in everything related to patient safety.

Comparación de la escala RACE con otras escalas de valoración de oclusiones arteriales de gran vaso en el medio extrahospitalario: una revisión rápida / Comparison of RACE scale to other assessment scales for large vessel arterial occlusions in the out-of-hospital level: a rapid review

Una proporción significativa de las enfermedadescerebrovasculares isquémicas se deben a oclusionesarteriales de grandes vasos (OAGV). Algunos serviciosde emergencias emplean escalas para detectar OAGV ydeterminar tanto el tratamiento como el centro médicomás adecuados para el paciente. El objetivo de esta re-visión fue comparar el valor predictivo para reconocerla presencia de una OAGV con la escala RACE frente aotras escalas destinadas al ámbito extrahospitalario.Se realizó una revisión rápida aplicando la meto-dología PRISMA en PubMed. Se seleccionaron veinteartículos enfocados en el entorno prehospitalario. Losinstrumentos evaluados con mayor frecuencia fueronNIHSS, CPSSS, LAMS y RACE. Las escalas evaluadas de-mostraron una precisión adecuada en la identificaciónde dicho evento, sin pretender reemplazar las pruebaspor imagen. RACE mostró un rendimiento predictivocomparable al resto de escalas, aunque inferior a la es-cala hospitalaria NIHSS, por lo que puede ser un instru-mento útil a nivel extrahospitalario.(AU)

A significant proportion of ischemic cerebrovascu-lar diseases are due to large vessel arterial occlusions(LVAO). Some emergency services utilize scales to de-tect LVAO and determine the most appropriate treat-ment and medical center for the patient. The aim of thisreview was to compare the predictive value of the RACEscale for recognizing the presence of a LVAO with otherscales used in the out-of-hospital setting.A rapid review was performed by applying the PRIS-MA methodology in PubMed. Twenty articles focusedon the prehospital setting were retained. The mostfrequently evaluated instruments were NIHSS, CPSSS,LAMS and RACE. The scales evaluated demonstrat-ed adequate precision in the identification of such anevent, without aiming to replace imaging tests. TheRACE showed a predictive performance comparable tothe other scales, although lower than the NIHSS hospi-tal scale, it may therefore be a useful instrument in theout-of-hospital setting.(AU)

[Comparison of RACE scale to other assessment scales for large vessel arterial occlusions in the out-of-hospital level: a rapid review].

A significant proportion of ischemic cerebrovascular diseases are due to large vessel arterial occlusions (LVAO). Some emergency services utilize scales to detect LVAO and determine the most appropriate treatment and medical center for the patient. The aim of this review was to compare the predictive value of the RACE scale for recognizing the presence of a LVAO with other scales used in the out-of-hospital setting. A rapid review was performed by applying the PRISMA methodology in PubMed. Twenty articles focused on the pre-hospital setting were retained. The most frequently evaluated instruments were NIHSS, CPSSS, LAMS and RACE. The scales evaluated demonstrated adequate precision in the identification of such an event, without aiming to replace imag-ing tests. The RACE showed a predictive performance comparable to the other scales, although lower than the NIHSS hospital scale, it may therefore be a useful instrument in the out-of-hospital setting.

Siringomas vulvares; cuando el diagnóstico diferencial es un reto / Vulvar syringomas; when differential diagnosis is a challenge

El interés de esta entidad radica en su adecuado diagnóstico, ya que es a menudo confundida con otros procesos patológicos. Esto tiene como consecuencia la realización de pruebas innecesarias y tratamientos ineficaces, con las implicaciones que ello pudiera tener. Los siringomas son tumoraciones benignas que tienen su origen en las glándulas sudoríparas ecrinas a nivel dérmico. Dada su benignidad clínica e histológica no requieren tratamiento específico. Los de localización genital, por su infrecuencia, suponen un reto diagnóstico y obligan al clínico a realizar un extenso diagnóstico diferencial con otras entidades nosológicas: condiloma plano, verruga vulgar, linfangioma circunscrito y quiste epidermoide, entre otros.(AU)

The interest in this condition lies in its correct diagnosis, since it can be easily misdiagnosed. As a consequence, patients are often tested and treated in many and empiric ways, with the impact that these actions could have. Syringomas are benign tumours originating from the dermic eccrine glands. Considering its clinical and histopathological benign behaviour, they do not require any specific treatment. Genital syringomas are usually difficult to identify, as such, on a first examination, owing to their infrequency and similarity with other pathological processes such as flat condylomas, vulgar warts, circumscribed lymphangioma, or epidermoid cyst, among others.(AU)

Vasculitis leucocitoclástica secundaria a nuevos anticoagulantes orales / Leucocytoclastic vasculitis secondary to new oral anticoagulants

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